FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a conjugate of a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor with an asialoglycoprotein receptor ligand for the treatment and prevention of cardiovascular diseases of general formula (I) and its pharmaceutically acceptable salts, where X represents either -OH or –NHAc, Y is
, 
,
, 
or 
,
a, b, c and d are each independently -H, -D or -CH3, k, l, m and n are each independently either 0, 1 or 2, Z is either alkyl (С2-С6), -O-, -S-, -NH-, -N(CH3)-, -NH-C(O)-, C(O)-NH-, -CH=CH- or -O-CH2-CH2-O-. The invention also relates to a method of producing the conjugate of formula (I), which does not require the use of potentially toxic transition metal catalysts.
(I)
EFFECT: obtaining of new conjugates of statins with asialoglycoprotein receptor ligands which are highly soluble and stable and can be used in medicine for the treatment of hyperlipidemia and atherosclerosis.
8 cl, 1 dwg, 1 tbl, 5 ex
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