FIELD: pharmaceuticals.
SUBSTANCE: invention relates to the field of medical chemistry and pertains to directed transport of medicinal products into the cells of the liver using molecules capable of binding to the transmembrane protein asialoglycoprotein. Proposed are new low molecular weight organic compounds - derivatives of quinoline-4-carboxylic acid by the general formula (I), wherein R = 8-Br, 8-I, 6-I, 6-C≡CH. Also described is a method for producing said compounds.
(I).
EFFECT: production of new heterocyclic compounds beneficial as directed transport of medicinal substances to the site of the disease.
11 cl, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CONJUGATES OF MONOMETHYL AURISTATIN E WITH ASIALOGLYCOPROTEIN RECEPTOR LIGANDS FOR TARGETED TRANSPORT INTO TUMOR CELLS OF LIVER | 2022 |
|
RU2809635C1 |
| CONJUGATE OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE INHIBITOR WITH ASIALOGLYCOPROTEIN RECEPTOR LIGAND | 2022 |
|
RU2816947C2 |
| LOW-MOLECULAR CONJUGATES OF ANTITUMOUR AGENTS AND HIGHLY SELECTIVE LIGANDS OF ASIALOGLYCOPROTEIN RECEPTOR FOR THERAPY OF ONCOLOGICAL LIVER PATHOLOGIES | 2017 |
|
RU2696096C2 |
| IONONE-BASED VANILLOID VRI RECEPTOR ANTAGONISTS | 2007 |
|
RU2447064C2 |
| ELECTROCHEMICAL METHOD FOR OBTAINING TETRAHYDROQUINOLINE DERIVATIVES, THEIR USE AS FUNGICIDAL AGENTS AND FUNGICIDAL COMPOSITIONS BASED ON THEM | 2022 |
|
RU2784323C1 |
| QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2 NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND USE THEREOF | 2012 |
|
RU2610262C2 |
| COMPOUNDS OF 2-AMINOCARBOXYLIC ACID SUBSTITUTED WITH 5-ARYL- -ISOXAZOLE-4-YL AND PHARMACEUTICAL COMPOSITION ON THEIR BASE | 1994 |
|
RU2138488C1 |
| MODULATORS OF ATP-BINDING CARTRIDGE TRANSPORTERS | 2005 |
|
RU2528046C2 |
| COMPOSITIONS AND METHODS OF TREATING ANDROGEN-RECEPTOR-POSITIVE CANCER | 2020 |
|
RU2817802C2 |
| 4-PIPERAZINYL-(8-QUINOLINYL)-METHYL)-BENZAMIDES, PHARMACEUTICAL COMPOSITION AND METHOD FOR PAIN TREATMENT | 2000 |
|
RU2260006C2 |
