FIELD: chemistry; biotechnology.
SUBSTANCE: invention relates to the field of organic and medical chemistry, as well as molecular biology and concerns a new class of compounds, which are candidates for means of delivering diagnostic compounds (agents) for diagnostics, including radio diagnostics or fluorescent diagnostics, or therapy of oncological diseases, including chemotherapy or radiotherapy. Disclosed is a compound of general formula (I), which is intended for preparing a conjugate with a drug or diagnostic agent for diagnosing or treating diseases caused by cells expressing PSMA, for example, such as prostate cancer cells. Disclosed means of delivering diagnostic or therapeutic agents, which include a PSMA ligand with a linker, have high affinity and selectivity for cells expressing PSMA. This property makes it possible to use them for treating diseases associated with high expression of PSMA, with a lower dosage with selective action on cancer cells, without affecting healthy cells.
EFFECT: disclosed delivery devices enable to combine active substances of different nature and mechanism of their action or use, including these delivery devices enable to perform combined chemotherapy of tumours expressing a prostatic specific membrane antigen, due to creation of bimodal conjugates on their basis.
14 cl, 25 dwg, 9 tbl, 67 ex
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