ANTI-RETROVIRAL COMBINATION Russian patent published in 2018 - IPC A61K9/48 A61K9/16 A61K9/20 A61K31/427 A61K31/635 A61K47/30 A61P31/18 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceutics. First invention is a pharmaceutical composition for use in the treatment of HIV or AIDS, comprising: first granules comprising ritonavir or a pharmaceutically acceptable salt or solvate thereof, and a water-insoluble polymer and / or a water-soluble polymer; second granules, including darunavir or a pharmaceutically acceptable salt or solvate thereof, where the dosage form is a capsule or sachet containing said first granules and second granules. Second invention is said pharmaceutical composition, wherein said first and second granules are compressed into first and second tablets, respectively, and placed in a capsule or sachet. Third invention is a method for producing said compositions.

EFFECT: group of inventions provides a stable solid pharmaceutical combination composition, which simplifies the dosage regimen and allows to reduce the drug load for the patient.

17 cl, 2 ex