FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a pharmaceutical composition in a tabletted dosage form which contains the first layer containing ritonavir and a polymer in a ratio of 1:1 - 1:6, and the second layer containing darunavir. The first layer is produced by hot extrusion, and the second layer - by direct extrusion or wet granulation. Also, the invention refers to a method for preparing the above pharmaceutical composition, and to a method of treating HIV or AIDS involving administering the above composition.
EFFECT: invention enables overcoming the incompatibility of ritonavir and darunavir, and also provides an optimum dissolution profile of both the active substances.
17 cl, 2 tbl, 2 ex
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