FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to psychiatry, and concerns the management of resistant depressive psychosomatic syndromes. That is ensured by parenteral introduction of tricyclic antidepressants combined with neuroleptics. Combination is obtained by mixing in 200 ml of physiologic saline successively 2.0–6.0 ml of 1.25 % clomipramine (anaphranil) and 1.0–2.0 ml of 0.2 % trifluoperazine (triftazine) solution. Administration is performed intravenously for 1.5–2 hours with control of arterial pressure and pulse every 30 minutes, followed by rest for 30–40 minutes, course of treating 12–14 infusions. That is followed by a strategic maintenance pathogenetic therapy for 6 months with the oral administration of clomipramine (anaphranil) in dose of 50–75 mg in a combination with trifluoperazine (triftazine) in dose of 2.5–5 mg.
EFFECT: introduction of such combination of medicinal preparations in the specified mode provides fast overcoming of therapeutic resistance in the given group of patients with minimum by-effects.
1 cl, 3 ex
