INHALATION PHARMACEUTICAL COMPOSITIONS Russian patent published in 2019 - IPC A61K9/14 A61K9/72 A61K31/137 A61K31/46 A61K47/26 A61J3/02 B02C17/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: described method of producing inhalation particles containing a pharmaceutically active agent comprising: a) dry milling a composition comprising a solid pharmaceutically active agent and a milled matrix in a mill which comprises a plurality of grinding bodies, for a period of time sufficient to obtain inhalation particles containing a solid pharmaceutically active agent and a milled matrix, where milling reduces the particle size of the solid pharmaceutically active agent to the median particle size based on the volume value between 50 nm and 3 mcm; and b) grinding the inhalation particles obtained at step a) in a mill without milling bodies for a period of time sufficient to obtain inhalation particles with a mean aerodynamic diameter (MMAD) between 1 mcm and 20 mcm.

EFFECT: two-step method for combined grinding of a pharmaceutically active agent and a milled matrix provides producing inhaled particles with improved characteristics.

32 cl, 2 dwg, 16 tbl