FLUORINE-CONTAINING INTEGRIN ANTAGONISTS Russian patent published in 2019 - IPC C07D471/04 A61K31/4375 A61K31/444 A61K31/506 A61P27/02 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula I or a pharmaceutically acceptable salt thereof, where Z is or ; R and R' denote H; Q is or ; X is CH or N; Y is CH or N; R₁ is C₁-C₄ alkyl substituted with 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms, or C₁-C₆ an alkoxy group substituted with 1, 2, 3, 4, 5, 6 or 7 fluorine atoms; and R₂ and R₃ independently of each other are H, F, CH₂F, CHF₂ or CF₃, provided that one of R₂ and R₃ is not H, provided that compound of formula I contains at least one fluorine atom. Invention also relates to a pharmaceutical composition based on a compound of formula I and use of the compound of formula I.

EFFECT: technical result is obtaining novel heterocyclic compounds effective for treating or preventing a disease mediated by αv integrin.

37 cl, 5 dwg, 9 tbl, 18 ex