NAPHTHYRIDIN DERIVATIVES AS ANTAGONISTS OF ALPHA V BETA 6 INTEGRIN FOR TREATING, IN PARTICULAR, FIBROTIC DISEASES Russian patent published in 2019 - IPC C07D471/04 A61K31/4375 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where R₁ is a five-membered aromatic heterocycle selected from N- or C-linked mono- or disubstituted pyrazole, N- or C-linked, optionally mono- or disubstituted triazole or N- or C-linked, optionally disubstituted imidazole, wherein the five-membered aromatic heterocycle can be substituted with one or two groups selected from a hydrogen atom, methyl group, ethyl group, fluorine atom, hydroxymethyl group, 2-hydroxypropane-2-yl group, trifluoromethyl group, difluoromethyl group or fluoromethyl group, except when R₁ is N-linked mono- or disubstituted pyrazole, R₁ is not 3,5-dimethyl-1H-pyrazol-1-yl, 5-methyl-1H-pyrazol-1-yl, 5-ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-diethyl-1H-pyrazol-1-yl, 4-fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-methyl-1H-pyrazol-1-yl or 1H-pyrazol-1-yl. Also described are methods for preventing or treating said diseases, a pharmaceutical composition based on the compound of formula (I) and use thereof.

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EFFECT: technical result is obtaining novel heterocyclic compounds, useful as antagonists α_vβ₆.

18 cl, 5 tbl, 15 ex