IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61P3/00 A61P9/00 A61P25/28 A61P27/00 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2695664 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (IIB) or a pharmaceutically acceptable salt thereof, where E denotes -CH₂-; Q is -CH₂- or -CH₂O-; Z is hydrogen or methyl; V denotes CR²² or N; R¹⁵ denotes a halogen or difluoromethoxy group; R¹⁶ is hydrogen or halogen; R²¹ denotes hydroxy, methoxy, piperazinyl or morpholinyl; R²² denotes hydrogen and R²³ denotes hydrogen. Invention also relates to a pharmaceutical composition based on a compound of formula (IIB), use thereof and a method of treating and/or preventing rheumatoid arthritis or Crohn's disease.

EFFECT: obtaining novel heterocyclic compounds having the properties of a TNFα activity modulator.

7 cl, 30 ex

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RU 2 695 664 C1

Authors

Dzhekson Viktoriya Elizabet

Porter Dzhon Robert

Dates

2019-07-25—Published

2014-12-08—Filed