FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and specifically to reversible inhibition of hepatocellular carcinoma in tumor cells of gene expression coding synthesis of apolipoprotein B. Method involves introducing a dispersion of lipid nanoparticles, such as nanoparticles of modified magnetite crystals, containing a related small interfering ribonucleic acid, complementary to a matrix ribonucleic acid coding sequence of apolipoprotein B in a tumor cell, into a medium with tumor cells of Huh7 hepatocellular human carcinoma. Then obtained mixture is treated for 1–3 h with alternating magnetic field with inductance of 50–100 millitesla.
EFFECT: invention increases degree of reversible inhibition in tumor cells of hepatocellular carcinoma of gene expression coding synthesis of apolipoprotein B.
1 cl, 4 ex
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