FIELD: biotechnology.
SUBSTANCE: what is described is a recombinant viral vector for treating and preventing cancer. Specifically described is a recombinant oncolytic virus containing one or more copies of two or more target sequences of tumor-suppressing micro-RNA (miR), inserted into two or more loci of viral genes required for viral replication, wherein the recombinant oncolytic virus is a herpes simplex virus (HSV), wherein two or more loci of viral genes required for viral replication contain an ICP4 locus, and the ICP4 locus comprises at least one copy of the target sequence of miR-124.
EFFECT: invention widens range of agents for treating cancer.
88 cl, 49 dwg, 8 tbl, 7 ex
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