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2 699 558

(13)

(51)

IPC

C07C335/24(2006-01-01)

A61K31/155(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018135078, 2018-10-05

(24)

Start date

2018-10-05

(22)

Actual filing date

2018-10-05

(45)

Published

2019-09-06

(72)

Inventor

Filimonova Marina VladimirovnaShevchenko Lyudmila IvanovnaFilimonov Aleksandr SergeevichKorneeva Tatyana SergeevnaSamsonova Alina Sergeevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Radiologii" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Radiologii" Minzdrava Rossii Rf)

AGENT FOR TARGETED THERAPY OF MALIGNANT GROWTHS Russian patent published in 2019 - IPC C07C335/24 A61K31/155 A61P35/00

Abstract RU 2699558 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 1-isobutanoyl-2-isopropyl isothiourea dichloroacetate (compound T1084) with the structural formula:

as a target therapeutic agent for solid malignant growths, having a complex anti-non-regional action – NOS-inhibiting anti-angiogenic and PDK1-inhibiting hypoxia-oriented cytotoxic.

EFFECT: providing effective and stable anti-tumor action and inhibiting (or inhibiting) development of tumor resistance to anti-angiogenic therapy, as well as broader capabilities for developing new pharmacological agents for complex targeted therapy of oncological diseases.

5 cl, 1 dwg, 3 tbl, 5 ex

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RU 2 699 558 C2

Authors

Filimonova Marina Vladimirovna

Shevchenko Lyudmila Ivanovna

Filimonov Aleksandr Sergeevich

Korneeva Tatyana Sergeevna

Samsonova Alina Sergeevna

Dates

2019-09-06—Published

2018-10-05—Filed