FIELD: chemistry.
SUBSTANCE: invention relates to 1-isobutanoyl-2-isopropyl isothiourea dichloroacetate (compound T1084) with the structural formula:
as a target therapeutic agent for solid malignant growths, having a complex anti-non-regional action – NOS-inhibiting anti-angiogenic and PDK1-inhibiting hypoxia-oriented cytotoxic.
EFFECT: providing effective and stable anti-tumor action and inhibiting (or inhibiting) development of tumor resistance to anti-angiogenic therapy, as well as broader capabilities for developing new pharmacological agents for complex targeted therapy of oncological diseases.
5 cl, 1 dwg, 3 tbl, 5 ex
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Year |
Author |
Number |
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2020 |
- Filimonova Marina Vladimirovna
- Shitova Anna Andreevna
- Soldatova Olga Vasilevna
- Shevchenko Liudmila Ivanovna
- Filimonov Aleksandr Sergeevich
- Podosinnikova Tatiana Sergeevna
- Saburova Alina Sergeevna
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2023 |
- Filimonova Marina Vladimirovna
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- Shitova Anna Andreevna
- Soldatova Olga Vasilevna
- Rybachuk Vitalii Aleksandrovich
- Nikolaev Kirill Anatolevich
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- Sharikova Irina Konstantinovna
- Kaprin Andrei Dmitrievich
- Shegai Petr Viktorovich
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| COMPLEX ANTIANGIOGENIC AND HYPOXIA-TARGETED ANTITUMOR AGENT |
2022 |
- Filimonova Marina Vladimirovna
- Shevchenko Liudmila Ivanovna
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- Koval Lidiia Semenovna
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|
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2017 |
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- Filimonov Aleksandr Sergeevich
- Shevchenko Lyudmila Ivanovna
- Chesnakova Ekaterina Aleksandrovna
- Galkin Vsevolod Nikolaevich
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|
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2023 |
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- Shegai Petr Viktorovich
- Kaprin Andrei Dmitrievich
|
RU2806650C1 |
| RADIOPROTECTIVE PHARMACOLOGICAL AGENT |
2020 |
- Filimonova Marina Vladimirovna
- Shevchenko Liudmila Ivanovna
- Filimonov Aleksandr Sergeevich
- Saburova Alina Sergeevna
- Makarchuk Viktoriia Mikhailovna
- Shitova Anna Andreevna
- Soldatova Olga Vasilevna
- Shegai Petr Viktorovich
- Ivanov Sergei Anatolevich
- Kaprin Andrei Dmitrievich
|
RU2733883C2 |
| ANTICANCER AGENT |
2012 |
- Filimonova Marina Vladimirovna
- Shevchenko Ljudmila Ivanovna
- Makarchuk Viktorija Mikhajlovna
- Shevchuk Aza Stepanovna
- Juzhakov Vadim Vasil'Evich
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|
RU2503450C1 |
| TUMOUR THERAPY AGENT |
2019 |
- Dmitrieva Mariya Vyacheslavovna
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- Kiseleva Marina Petrovna
- Golubeva Irina Sergeevna
- Ektova Lidiya Vladimirovna
- Eremina Vera Aleksandrovna
- Tikhonova Nadezhda Ivanovna
- Orlova Olga Lvovna
- Nikolaeva Lyudmila Leonidovna
- Shprakh Zoya Sergeevna
- Lantsova Anna Vladimirovna
- Gusev Dmitrij Vasilevich
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- Oborotova Nataliya Aleksandrovna
- Kulbachevskaya Nataliya Yurevna
- Konyaeva Olga Ivanovna
- Ermakova Nadezhda Pavlovna
|
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2022 |
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- Surinova Valentina Ivanovna
- Soldatova Olga Vasilevna
- Shitova Anna Andreevna
- Tsyshkova Nina Gavrilovna
- Filimonov Aleksandr Sergeevich
- Shegai Petr Viktorovich
- Kaprin Andrei Dmitrievich
|
RU2782931C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING MALIGNANT GROWTHS OF PROSTATE GLANDS |
2015 |
|
RU2589266C1 |
