FIELD: chemistry.
SUBSTANCE: invention relates to 1-isobutanoyl-2-isopropyl isothiourea dichloroacetate (compound T1084) with the structural formula:
as a target therapeutic agent for solid malignant growths, having a complex anti-non-regional action – NOS-inhibiting anti-angiogenic and PDK1-inhibiting hypoxia-oriented cytotoxic.
EFFECT: providing effective and stable anti-tumor action and inhibiting (or inhibiting) development of tumor resistance to anti-angiogenic therapy, as well as broader capabilities for developing new pharmacological agents for complex targeted therapy of oncological diseases.
5 cl, 1 dwg, 3 tbl, 5 ex
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Authors
Dates
2019-09-06—Published
2018-10-05—Filed