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2 804 771

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IPC

C07C335/38(2006-01-01)

A61K31/155(2006-01-01)

A61P35/00(2006-01-01)

C07C255/34(2006-01-01)

(21) (22)

Application

2022125924, 2022-10-04

(24)

Start date

2022-10-04

(22)

Actual filing date

2022-10-04

(45)

Published

2023-10-05

(72)

Inventor

Filimonova Marina VladimirovnaShevchenko Liudmila IvanovnaFilimonov Aleksandr SergeevichShitova Anna AndreevnaSoldatova Olga VasilevnaSurinova Valentina IvanovnaKoval Lidiia SemenovnaGrekova Raisa Dmitrievna

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Imeni V.A. Almazova» Ministerstva Zdravookhraneniia Rossiiskoi Federatsii

COMPLEX ANTIANGIOGENIC AND HYPOXIA-TARGETED ANTITUMOR AGENT Russian patent published in 2023 - IPC C07C335/38 A61K31/155 A61P35/00 C07C255/34

Abstract RU 2804771 C1

FIELD: medicine.

SUBSTANCE: invention is related to a complex antiangiogenic and hypoxia-oriented antitumor agent containing the chemical compound 1-cyclohexanoyl-2-ethylisothioureaα-cyano-4-hydroxycinnamate as an active substance of general formula (I), which has NOS-inhibitory and MCT-inhibitory activity and has a combined antiangiogenic and hypoxia-oriented toxic effect on neoplasia.

EFFECT: complex antiangiogenic and hypoxia-oriented antitumor agent that provides a more pronounced, stable and long-lasting antitumor effect against neoplasia of various histogenesis, without increasing toxic effects.

2 cl, 3 tbl, 3 ex

(I)

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RU 2 804 771 C1

Authors

Filimonova Marina Vladimirovna

Shevchenko Liudmila Ivanovna

Filimonov Aleksandr Sergeevich

Shitova Anna Andreevna

Soldatova Olga Vasilevna

Surinova Valentina Ivanovna

Koval Lidiia Semenovna

Grekova Raisa Dmitrievna

Dates

2023-10-05—Published

2022-10-04—Filed