E-2-ARYL-2-TRIFLUOROMETHYL-1-NITRO-CYCLOPROPANES AND A METHOD FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC C07C13/04 C07C22/08 C07D213/16 A61K31/04 A61K31/75 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to E-2-aryl-2-trifluoromethyl-1-nitro-cyclopropane of general formula I, where X=C, R=R₁=H; X=C, R=Cl, R₁=H; X=C, R=R₁=Cl; X=C, R=Br, R₁=H; X=C, R=R₁=Br; X=C, R=C₁-C₃-alkyl, R₁=H; X=C, R=NO₂, R₁=H; X=C, R=CO₂Alk, R₁=H; X=C, R=CF₃, R₁=H; X=C, R=OMe, R₁=H; X=C, R=R₁=OMe; X=C, R=F, R₁=H; X=C, R-R₁=-OCH₂O-; X=N, R=R₁=H. Also disclosed is a method of producing compounds I, consisting in batch addition of 4-15-fold molar excess of bromonitromethane and inorganic (preferably potassium carbonate) or organic (preferably 1,1-dimethyl-1,4,5,6-tetrahydropyrimidine) base to a solution of the corresponding α-(trifluoromethyl)styrene in a polar solvent, preferably dimethylsulphoxide (in case of an inorganic base) and 1,1,3,3-tetramethyl urea or N,N-dimethylformamide (in the case of an organic base) at room temperature.

EFFECT: obtaining novel compounds which can be used in medicine as anticancer agents for rectal cancer cells and human myelogenous leukemia.

7 cl, 1 tbl, 14 ex