COMPOSITIONS WITH PROLONGED RELEASE, OBTAINED FROM HYALURONIC ACID, AND THERAPEUTIC APPLICATIONS THEREOF Russian patent published in 2019 - IPC A61K31/728 A61K47/10 A61K9/10 A61K9/14 A61P17/00 A61P19/00 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to polymer particles which provide prolonged diffusion of hyaluronic acid. Polymer particles consist of at least a copolymer of poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) or a poly(lactic-co-glycolic acid) (PLGA) polymer mixture and a poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) copolymer combined with hyaluronic acid molecules acid or with hyaluronic acid salts, and where the poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) copolymer has a molecular weight varying from 50,000 to 70,000 g⋅mol^-1. Invention also discloses a method of producing polymer particles, an injectable hyaluronic acid composition, a method of preparing the composition, use of a composition for controlling skin aging and for repairing skin tissue, a kit for preparing an injectable hyaluronic acid composition.

EFFECT: group of inventions provides a slow release profile of hyaluronic acid.

31 cl, 6 dwg, 8 tbl, 4 ex