ANTIBODIES TO B7-H1 FOR TREATING TUMOURS Russian patent published in 2019 - IPC A61K39/395 

Abstract RU 2701327 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and represents an antibody which specifically binds to B7-H1, or an antigen-binding fragment thereof for use in treating a patient having a tumour which expresses B7-H1, wherein the patient is detected by detecting B7-H1 expression in one or more tumour cells, and where 25 % or more tumour cells contain membrane staining by B7-H1, where the use additionally involves using 0.1, 0.3, 1, 3, 10, or 15 mg/kg of antibody or its antigen-binding fragment.

EFFECT: invention allows extending the range of antibodies to B7-H1.

11 cl, 25 dwg, 19 tbl, 4 ex

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RU 2 701 327 C2

Authors

Narval Radzhesh

Ferman Devid

Robbins Pol

Liang Mejna

Shnejder Emi

Chaves Karlos

Kherl Karina

Pak Min

Lu Khun

Rebelatto Marlon

Stil Kejt

Butrin Anmari

Si Li

Khong Shenyan

Khiggs Brendon

Roskos Lorin

Dates

2019-09-25Published

2014-09-11Filed