FIELD: biotechnology.
SUBSTANCE: described is a group of inventions involving a method of treating malignant growths containing tumor stem cells (TSC), wherein said method comprises administering to a patient an effective amount of an antibody or antigen-binding fragment thereof, specifically binding to O-acetylated GD2 ganglioside, a pharmaceutical composition for treating malignant growths, method in vitro diagnosing a malignant growth, using O-acetylated GD2 ganglioside as a malignant new growth biomarker, a method for predicting a response of a patient having a malignant growth. In one embodiment, the malignant disease is selected from leukaemia, breast cancer, glioma, colorectal cancer, pancreatic cancer, prostate cancer and lung cancer.
EFFECT: invention extends the range of products for treating and diagnosing malignant growths.
25 cl, 6 dwg, 3 tbl, 4 ex
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|---|---|---|---|
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|
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