FIELD: biotechnology.
SUBSTANCE: selective bifunctional protein complex is proposed that suppresses growth and/or causes apoptosis of cancer stem cells, consisting of two fragments of the variable parts of VHH-camel antibodies, capable of recognizing and selectively binding to the CD47 and CD44 cellular receptors, where the fragments are linked together into a single polypeptide chain by a polypeptide linker.
EFFECT: this complex possesses a high specificity, bioavailability, and, in comparison with traditional monoclonal antibodies, highly effective and selectively affects cancer stem cells, while having a minimal effect on the normal cells of the patient's body.
1 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SELECTIVE BIFUNCTIONAL DRUG ON THE BASIS OF FRAGMENTS OF CAMELIZED SINGLE-CHAIN ANTIBODIES, AIMED TO ONCOTIC RECEPTORS CD47/ERBB2, INTENDED FOR THE THERAPY OF MALIGNANT NEOPLASMS | 2016 |
|
RU2648164C1 |
| NK CELL LINE EXPRESSING PSMA-SPECIFIC CHIMERIC ANTIGEN RECEPTOR AND SECRETING CD47/SIRPA INTERACTION BLOCKER | 2020 |
|
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| USE OF O-ACETYLATED GD2 GANGLIOSIDE AS TARGET AS NOVEL THERAPEUTIC AND DIAGNOSTIC APPROACH IN MALIGNANT GROWTHS CONTAINING TUMOUR STEM CELLS | 2014 |
|
RU2702428C2 |
| GENETIC CONSTRUCT CODING STRUCTURE OF T-CELL CHIMERIC RECEPTOR BASED ON SINGLE-CHAIN VHH ANTIBODIES SPECIFIC TO TUMOUR RECEPTOR CD47 FOR THE TARGETED IMMUNOTHERAPY OF MALIGNANT GROWTHS | 2017 |
|
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| DIAGNOSTICS AND TREATMENT OF CANCER ASSOCIATED WITH CANCER STEM CELLS | 2014 |
|
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| RECOMBINANT STRAIN OF HERPESVIRUS SAIMIRI FOR OBTAINING POPULATIONS OF IMMORTALISED AUTOLOGOUS T LYMPHOCYTES EXPRESSING PAIRED CHIMERIC RECEPTORS AGAINST CD44 AND CD133 TUMOUR ANTIGENS | 2020 |
|
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| ANTIBODIES SPECIFIC TO TUMOUR AND USE THEREOF | 2011 |
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| COMPOSITIONS AND METHODS OF IMMUNOTHERAPY | 2014 |
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| ANTIBODIES AGAINST CCR7 RECEPTOR FOR CANCER TREATMENT | 2006 |
|
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| AGENTS LINKING FRIZZLED RECEPTOR AND THEIR USE | 2009 |
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RU2579897C2 |
