FIELD: biotechnology.
SUBSTANCE: disclosed is a multimeric antibody which recognizes ganglioside OAcGD2 for the selective delivery of at least one anti-cancer agent having a molecular weight in range of 100 to 200,000 Da, into a cell expressing ganglioside OAcGD2. Said antibody is used in a composition and method for delivering an anti-cancer agent into a cell expressing ganglioside OAcGD2, in a method for increasing the effectiveness of treating cancer expressing ganglioside OAcGD2 using an anticancer agent, in methods for preventing and treating refractory or recurrent cancer in a patient.
EFFECT: invention provides a synergistic effect of a combined treatment with an antibody specifically targeting ganglioside OAcGD2, and anticancer agents on forms of cancer expressing ganglioside OAcGD2, which enables to reduce dosages and, consequently, toxic side effects from anticancer agents.
22 cl, 7 dwg, 6 tbl
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