METHOD FOR PREDICTION OF SURVIVAL RATE IN PATIENTS WITH LUNG ADENOCARCINOMA CARRYING A MUTATION IN THE KRAS GENE Russian patent published in 2019 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and enables predicting the survival rate of the patients with pulmonary adenocarcinoma. Method for prediction of survival rate in patients with lung adenocarcinoma carrying a mutation in the KRAS gene involves sampling tumor tissue fragments in a patient with pulmonary adenocarcinoma after surgical removal of tumor tissue, of which a portion is used to detect the presence of mutations in the KRAS gene, and a portion for RNA recovery, if mutations are detected in the KRAS gene from RNA samples, cDNA libraries are prepared for sequencing and sequenced, normalizing expression of constant immunoglobulin heavy chain constant gene genes is determined from the sequencing data IGHG1, IGHG2, IGHG3, IGHG4, IGHA1, IGHA2, calculating coefficient K by formula K=IGHG1/IGH, where IGH=IGHG1+IGHG2+IGHG3+IGHG4+IGHA1+IGHA2, and if K>0.14, the prediction is considered to be favorable, otherwise – not favorable.

EFFECT: what is presented is a method for prediction of survival rate in patients with lung adenocarcinoma carrying a mutation in the KRAS gene.

1 cl, 2 ex