METHOD OF CREATING TARGET PANEL FOR STUDYING GENOMIC REGIONS FOR DETECTING THERAPEUTIC BIOMARKERS OF IMMUNE CHECKPOINT (IC) INHIBITORS Russian patent published in 2024 - IPC C12Q1/686 C12Q1/6874 C40B50/06 

Abstract RU 2818360 C1

FIELD: biotechnology.

SUBSTANCE: described is a method of creating a target panel for investigating target genomic regions to identify predictive genetic biomarkers of potential effectiveness and/or resistance to immune checkpoint (CI) inhibitors. Method involves genetic analysis of resection or biopsy material of tumor tissue of patient with diagnosed malignant neoplasm (MNP) before the beginning of the course or during immunotherapy based on immune checkpoint inhibitors—anti-PD-l or anti-PD-L1 preparations, namely: laboratory extraction of DNA from a sample of tumor material, measurement of concentration of extracted DNA, preparation of DNA libraries using tumor DNA as a matrix for amplification of target genomic regions during PCR with specific primers, sequencing of DNA libraries, subsequent bioinformatic processing of sequencing results, interpretation of biological and clinical significance of genetic variants detected by results of targeted sequencing, identification of predictive genetic biomarkers of potential efficacy and/or resistance to immunotherapy with immune checkpoint inhibitors based on target genome regions including coding sequences of 34 genes: JAK3, JAK2, MDM2, CD274, PBRM1, B2M, ERBB2, IFNGR1, CD8A, JAK1, MET, BAP1, POLE, POLD1, EGFR, LAG3, BRAF, HAVCR2, MLH1, KRAS, IFNG, ALK, PIK3CA, IDO1, AXL, TP53, STATI, SMAD4, ROS1, ARID1A, PTEN, PDCD1LG2, STK11, VHL), as well as sections of 9p24.1 locus: genes JAK2, PD-L1, and PD-L2 and intergenic regions.

EFFECT: invention can be used for selection of anticancer therapy or determination of its possible effectiveness.

12 cl, 5 tbl

Similar patents RU2818360C1

Title Year Author Number
METHOD OF DIFFERENTIAL DIAGNOSTICS OF TYPE OF STOMACH CANCER BY IMMUNOHISTOCHEMICAL TESTING METHOD 2023
  • Danilova Natalya Vladimirovna
  • Malkov Pavel Georgievich
  • Olejnikova Nina Aleksandrovna
RU2813670C1
METHOD FOR MINIMALLY INVASIVE DIAGNOSIS OF LUNG CANCER BY FRAGMENTED CIRCULATING FREE DNA BASED ON MACHINE LEARNING METHODS 2023
  • Yudin Sergej Mikhajlovich
  • Keskinov Anton Arturovich
  • Makarov Valentin Vladimirovich
  • Yudin Vladimir Sergeevich
  • Meshkov Ivan Olegovich
  • Makarova Anna Sergeevna
  • Kotyurgin Aleksandr Pavlovich
  • Ershov Pavel Viktorovich
  • Snigir Ekaterina Andreevna
  • Makhotenko Antonida Viktorovna
  • Astafeva Vasilisa Aleksandrovna
  • Maralova Ekaterina Dmitrievna
  • Fedorov Artem Yurevich
RU2820322C1
METHOD FOR PREDICTION OF CLINICAL EFFECTIVENESS IN MELANOMA 2021
  • Kiselevskij Mikhail Valentinovich
  • Anisimova Natalya Yurevna
  • Petkevich Alisa Antonovna
  • Reshetnikova Vera Vladimirovna
  • Artamonova Elena Vladimirovna
  • Zabotina Tatyana Nikolaevna
  • Kadagidze Zaira Grigorevna
  • Samojlenko Igor Vyacheslavovich
RU2766739C1
METHOD OF OBTAINING A CULTURE OF LYMPHOCYTES ENRICHED IN TUMOR-SPECIFIC T-LYMPHOCYTE CLONES AND CELL CULTURES OBTAINED USING THE SPECIFIED METHOD 2022
  • Bryushkova Ekaterina Aleksandrovna
  • Sharonov Georgij Vladimirovich
  • Lukyanov Sergej Anatolevich
  • Chudakov Dmitrij Mikhajlovich
  • Serebrovskaya Ekaterina Olegovna
RU2808595C1
VEGF POLYMORPHISM AND ANTIANGIOGENESIS THERAPY 2008
  • Shnajder Brajan P.
  • Radovich Milan
  • Sledzh Dzhordzh U.
RU2482491C2
METHODS OF DETECTING AND MONITORING CANCER BY PERSONALIZED DETECTION OF CIRCULATING TUMOR DNA 2019
  • Tsimmerman, Bernkhard
  • Salari, Rakhelekh
  • Suenerton, Rajan
  • U, Sin-Ta
  • Seti, Khimanshu
RU2811503C2
VEGF POLYMORPHISM AND ANTIANGIOGENESIS THERAPY 2013
  • Shnajder, Brajan P.
  • Radovich, Milan
  • Sledzh, Dzhordzh U.
RU2635525C2
BIOMARKER PANEL AND METHODS FOR DETECTING MICROSATELLITE INSTABILITY IN VARIOUS TYPES OF CANCER 2019
  • De Craene, Bram
  • Decanniere, Klaas
  • Van De Velde, Jan
  • Maertens, Geert
RU2795410C2
GENETIC VECTOR Ad6/3-hTERT-GMCSF CONTAINING GENOMIC SEQUENCES OF RECOMBINANT ADENOVIRUS SEROTYPE 6, HUMAN TELOMERASE PROMOTER, HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GENE, AS WELL AS FIBER PROTEIN GENE WITH INSERTION OF FIBER KNOB DOMAIN OF ADENOVIRUS SEROTYPE 3 WITH INCREASED TRANSDUCTION INTO TUMOR CELLS 2023
  • Yudin Sergej Mikhajlovich
  • Keskinov Anton Arturovich
  • Makarov Valentin Vladimirovich
  • Fedoseeva Darya Mikhajlovna
  • Nazarov Anton Sergeevich
  • Netesov Sergej Viktorovich
  • Romanenko Margarita Vladimirovna
  • Osipov Ivan Dmitrievich
  • Vasikhovskaya Valeriya Aleksandrovna
  • Kutsejkin Sergej Sergeevich
RU2814581C1
METHOD FOR DETERMINING MARKERS OF PRESENCE OF TUMOR T-LYMPHOBLASTS 2016
  • Lebedev Yurij Borisovich
  • Mamedov Ilgar Ziyaddinovich
  • Shcheglov Aleksandr Sergeevich
  • Minervina Anastasiya Alekseevna
RU2674994C2

RU 2 818 360 C1

Authors

Yudin Sergej Mikhajlovich

Keskinov Anton Arturovich

Makarov Valentin Vladimirovich

Yudin Vladimir Sergeevich

Makarova Anna Sergeevna

Kotyurgin Aleksandr Pavlovich

Bugaev-Makarovskij Nikolaj Andreevich

Ershov Pavel Viktorovich

Snigir Ekaterina Andreevna

Makhotenko Antonida Viktorovna

Maralova Ekaterina Dmitrievna

Vanyushina Yuliya Nikolaevna

Kikot Aleksandra Denisovna

Dates

2024-05-02Published

2023-07-10Filed