METHOD OF DIFFERENTIAL DIAGNOSTICS OF TYPE OF STOMACH CANCER BY IMMUNOHISTOCHEMICAL TESTING METHOD Russian patent published in 2024 - IPC A61B8/06 

FIELD: biotechnology.

SUBSTANCE: method of classifying molecular subtypes of gastric cancer by immunohistochemical testing is described, the said method involves an original algorithm for step-by-step immunohistochemical testing of gastric cancer, including a panel of the following markers: MSH2, MSH6, MLH1, PMS2, MUC2, CDX2, MUC5AC, CD10, E-cadherin, β-catenin, Claudin-1, Claudin-3, Claudin-4, CD44, LMP-1, EBER, p53, PD-L1, CD4, CD8, CD68, CD1a. The method makes it possible to identify 5 molecular subtypes of gastric cancer with significantly different clinical, morphological and prognostic characteristics. The algorithm provides for the identification of the MMR-negative subtype at the first stage, the EBER-positive subtype at the second stage, then the E-cadherin-aberrant subtype, then the CDX2-positive subtype and the CDX2-negative subtype, since in this option the differences between the subtypes are of the greatest significance (p=0.001).

EFFECT: invention expands the range of diagnostic tools for stomach cancer.

4 cl, 6 dwg, 1 tbl, 2 ex