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(19)

(11)

2 703 454

(13)

(51)

IPC

C07D401/12(2006-01-01)

C07D401/14(2006-01-01)

C07D405/14(2006-01-01)

C07D491/22(2006-01-01)

C07D491/147(2006-01-01)

C07D498/18(2006-01-01)

C07D305/14(2006-01-01)

A61K31/4353(2006-01-01)

A61K31/437(2006-01-01)

A61K31/444(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2016150435, 2015-05-18

(24)

Start date

2015-05-18

(22)

Actual filing date

2015-05-18

(45)

Published

2019-10-17

(72)

Inventor

Chen, Chiung-TongShia, Kak-ShanWu, Chien-HuangTsou, Lun-KelvinChao, Yu-Sheng

(73)

Holder

Molecular Targeting Technologies, Inc.National Health Research Institutes

DIPICOLYLAMINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF Russian patent published in 2019 - IPC C07D401/12 C07D401/14 C07D405/14 C07D491/22 C07D491/147 C07D498/18 C07D305/14 A61K31/4353 A61K31/437 A61K31/444 A61P35/00

Abstract RU 2703454 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I), where each of A₁, A₂, A₃, A₄, A₅ and A₆ is methylene; B₁ is ethylene, butylene or hexylene; B₂ is a bond, ethylene, phenylene, , , , , , , or ; L₁ is a bond, NH, NHCH₂, NHC(O), NHSO₂, NHC(O)NH, or ; L₂ is CO; each of W₁, W₂, W₃, W₄, W₅, W₆, W₇ and W₈ is CH; or each of W₁, W₂, W₃, and W₄ is N, and each of W₅, W₆, W₇ and W₈ is CH; X is a bond, O or NH; Y is or ; and Z is or . Invention also relates to specific compounds, a pharmaceutical composition based on compound of formula (I) and Zn²⁺ and a method of treatment.

EFFECT: technical result is obtaining a novel heterocyclic compound useful for treating a condition associated with cells containing "turned-out" phosphatidylserine.

12 cl, 2 tbl, 51 ex

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RU 2 703 454 C2

Authors

Chen, Chiung-Tong

Shia, Kak-Shan

Wu, Chien-Huang

Tsou, Lun-Kelvin

Chao, Yu-Sheng

Dates

2019-10-17—Published

2015-05-18—Filed