FIELD: chemistry.
SUBSTANCE: invention relates to use of 1,2,4-triazole derivatives of formula I:
, where R1, R2 and R3 independently denote hydrogen or halogen; R4 denotes C1-C6 alkyl; R5 and R6 independently denote C1-C6 alkyl or, together with a nitrogen atom to which they are bonded, form a 5-7-member heterocyclyl group, in which the 6-member heterocyclyl can further contain one oxygen or nitrogen atom and can be substituted with acetyl, C1-C6 alkyl or phyenyl; X-S-, -SO-, -SO2- or O; and n is a whole number selected from 1-8; or pharmaceutically acceptable salts, stereoisomers or solvates thereof, when producing a drug for treating or preventing sigma-1 receptor-mediated diseases or conditions, methods of producing said compounds, intermediate compounds and pharmaceutical compositions which contain compounds of formula 1.
EFFECT: improved compounds.
19 cl, 49 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SIGMA-RECEPTOR INHIBITORS | 2005 |
|
RU2417987C2 |
| SIGMA-LIGANDS FOR APPLICATION IN PREVENTION AND/OR TREATMENT OF POSTOPERATIVE PAIN | 2011 |
|
RU2569055C2 |
| PROLYL HYDROXYLASE INHIBITORS | 2010 |
|
RU2518071C2 |
| SIGMA-RECEPTOR INHIBITORS | 2005 |
|
RU2404972C2 |
| DERIVATIVES OF 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDEAS LIGANDS OF RECEPTOR CANNABINOIDS | 2003 |
|
RU2325382C2 |
| SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-7-YL COMPOUNDS AS THE INHIBITORS OF PDE2 | 2015 |
|
RU2659070C9 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| TYPE 1 DIACYLGLYCEROL-O-ACYLTRANSFERASE ENZYME INHIBITORS | 2008 |
|
RU2486186C2 |
| 1,2,4-TRIAZOLONE DERIVATIVE | 2011 |
|
RU2566754C2 |
| COMPOSITIONS AND METHODS OF TREATING COLITIS | 2010 |
|
RU2518416C2 |
