FIELD: chemistry.
SUBSTANCE: present invention relates to a compound of formula (I) in form of a base, an enantiomer, a diastereomer, including a racemic mixture, and an additive salt with an acid, which is a direct safe inhibitor of the mitochondrial respiratory chain 1 complex and an indirect inhibitor of stabilizing a hypoxia-inducible factor (HIF-1), hypoxic stress, versions of the method for preparing it, an intermediate compound for preparing the compound of formula (I), as well as a medicinal agent and a pharmaceutical composition containing the disclosed compound of formula (I).
(I).
In formula (I) A is 5-member heteroaryl group containing 1 to 3 heteroatoms, where at least one heteroatom is selected from a sulfur atom and a nitrogen atom, where A is unsubstituted or substituted with one (C1-C4) alkyl group, and said (C1-C4) alkyl group is unsubstituted or substituted with a heterocyclyl group, each of R1, R2, R1' and R2', independently, represents a hydrogen atom or a (C1-C4) alkyl group, and each of R3, R4, R5, R3', R4' and R5', independently, is selected from a hydrogen atom, halogen atom, -O-fluoromethyl group and (C1-C4) alkoxy group, where at least one of R3, R4 and R5 is (C1-C4) alkoxy group, and at least one of R3', R4' and R5' represents a (C1-C4) alkoxy group.
EFFECT: disclosed are benzylhydroxide derivatives, their preparation and therapeutic application thereof.
20 cl, 1 tbl, 26 ex
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