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2 530 553

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(51)

IPC

C07K16/24(2006-01-01)

C12N15/13(2006-01-01)

A61K39/395(2006-01-01)

A61P29/00(2006-01-01)

G01N33/53(2006-01-01)

(21) (22)

Application

2012147173/10, 2012-11-07

(24)

Start date

2012-11-07

(22)

Actual filing date

2012-11-07

(45)

Published

2014-10-10

(72)

Inventor

Tillib Sergej VladimirovichEfimov Grigorij AleksandrovichNedospasov Sergej ArturovichKruglov Andrej AlekseevichDrutskaja Marina Sergeevna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Imeni M.V. Lomonosova"

RECOMBINANT SINGLE-DOMAIN ANTIBODY ABLE TO BIND HUMAN TUMOUR NECROSIS FACTOR SPECIFICALLY AND ITS DERIVATIVES Russian patent published in 2014 - IPC C07K16/24 C12N15/13 A61K39/395 A61P29/00 G01N33/53

Abstract RU 2530553 C2

FIELD: medicine.

SUBSTANCE: invention refers to immunology and biotechnology. What is presented is a single-domain antibody (VHH) able to bind the cytokine human necrosis factor (TNF), a DNA fragment coding the antibody according to the invention, as well as a method for identifying the human TNF and measuring it in a biological sample.

EFFECT: invention provides the specific block of macrophague-monocytic TNF cells and can find further application in therapy of the diseases associated with an undesired TNF-dependent inflammatory response.

4 cl, 5 ex, 7 dwg

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RU 2 530 553 C2

Authors

Tillib Sergej Vladimirovich

Efimov Grigorij Aleksandrovich

Nedospasov Sergej Arturovich

Kruglov Andrej Alekseevich

Drutskaja Marina Sergeevna

Dates

2014-10-10—Published

2012-11-07—Filed