Show metadata Hide metadata

(19)

(11)

2 530 553

(13)

(51)

IPC

C07K16/24(2006-01-01)

C12N15/13(2006-01-01)

A61K39/395(2006-01-01)

A61P29/00(2006-01-01)

G01N33/53(2006-01-01)

(21) (22)

Application

2012147173/10, 2012-11-07

(24)

Start date

2012-11-07

(22)

Actual filing date

2012-11-07

(45)

Published

2014-10-10

(72)

Inventor

Tillib Sergej VladimirovichEfimov Grigorij AleksandrovichNedospasov Sergej ArturovichKruglov Andrej AlekseevichDrutskaja Marina Sergeevna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Imeni M.V. Lomonosova"

RECOMBINANT SINGLE-DOMAIN ANTIBODY ABLE TO BIND HUMAN TUMOUR NECROSIS FACTOR SPECIFICALLY AND ITS DERIVATIVES Russian patent published in 2014 - IPC C07K16/24 C12N15/13 A61K39/395 A61P29/00 G01N33/53

Abstract RU 2530553 C2

FIELD: medicine.

SUBSTANCE: invention refers to immunology and biotechnology. What is presented is a single-domain antibody (VHH) able to bind the cytokine human necrosis factor (TNF), a DNA fragment coding the antibody according to the invention, as well as a method for identifying the human TNF and measuring it in a biological sample.

EFFECT: invention provides the specific block of macrophague-monocytic TNF cells and can find further application in therapy of the diseases associated with an undesired TNF-dependent inflammatory response.

4 cl, 5 ex, 7 dwg

Similar patents RU2530553C2

Title	Year	Author	Number
SINGLE-DOMAIN ANTIBODY aMts1 SPECIFICALLY BINDING PROTEIN S100A4/Mts1, METHOD FOR PREPARING AND USING FOR DETECTION OF THIS PROTEIN	2012	Tillib Sergej Vladimirovich	RU2484096C1
NANOANTIBODY SPECIFICALLY BINDING MUC1 PROTEIN, METHOD OF MUC1 PROTEIN DETECTION BY NANOANTIBODIES	2012	Tillib Sergej Vladimirovich	RU2493165C1
SINGLE-DOMAIN MINI-ANTIBODY aHER2/aSKBR3-1, SPECIFICALLY BINDING EPIDERMAL GROWTH FACTOR RECEPTOR HER2/ERBB2/neu AND CAPABLE TO PENETRATE THROUGH THIS INTERACTION INTO TARGET CELLS (INTERNALISED), METHOD OF PRODUCTION OF THIS ANTIBODY AND METHOD OF DETECTION OF PROTEIN HER2/ERBB2/neu AND CELLS EXPRESSING THIS PROTEIN IN INCREASED AMOUNT, USING MINI-ANTIBODY aHER2/aSKBR3-1	2012	Tillib Sergej Vladimirovich Ivanova Tat'Jana Il'Inichna Vasil'Ev Lev Anatol'Evich Deev Sergej Mikhajlovich Zdobnova Tat'Jana Aleksandrovna Zagajnova Elena Vadimovna	RU2522929C2
NANOANTIBODIES BINDING CHLAMYDIA TRACHOMATIS ANTIGEN, METHOD OF INHIBITING INFECTION CAUSED BY CHLAMYDIA TRACHOMATIS	2012	Zigangirova Nailja Akhatovna Tillib Sergej Vladimirovich	RU2487724C1
NANOANTIBODY SPECIFICALLY BINDING CEA PROTEIN, METHOD OF ITS USAGE FOR DETECTION OF THIS PROTEIN	2012	Tillib Sergej Vladimirovich	RU2493166C1
RECOMBINANT SINGLE-DOMAIN ANTIBODIES SPECIFICALLY BINDING HUMAN INTERLEUKIN-6, METHOD FOR THEIR PREPARING AND USING FOR DETECTION OF THIS PROTEIN	2015	Tillib Sergej Vladimirovich Nedospasov Sergej Arturovich Efimov Grigorij Aleksandrovich Drutskaja Marina Sergeevna Kruglov Andrej Alekseevich Gorjajnova Oksana Sergeevna Ivanova Tatjana Ilinichna	RU2603269C1
HUMANISED ANTIBODY TO TNF-α, ITS ANTIGEN-BINDING FRAGMENT (Fab) AND THEIR APPLICATION	2011	Keh, Sjao Gao, Sjaopin	RU2556815C2
NANOANTIBODIES aMh1, aMh2 BINDING ANTIGEN OF MYCOPLASMA HOMINTS, METHOD OF PRODUCING THEM, METHOD OF TREATING MYCOPLASMA HOMINIS INFECTION	2011	Logunov Denis Jur'Evich Tillib Sergej Vladimirovich	RU2484095C1
SINGLE-DOMAIN ANTIBODY SPECIFICALLY BINDING HUMAN ERBB3 RECEPTOR, WITHOUT CANONICAL DISULPHIDE BOND	2018	Yudenko Anna Nikolaevna Eliseev Igor Evgenevich Ukrainskaya Valeriya Mikhajlovna Chakchir Oleg Borisovich	RU2721854C1
RECOMBINANT PLASMID DNA PET3.54, ENCODING POLYPEPTIDE FN3.54, INTERACTING WITH HUMAN TUMOUR NECROSIS FACTOR, AND STRAIN OF BACTERIA ESCHERICHIA COLI - PRODUCER OF POLYPEPTIDE FN3.54, INTERACTING WITH HUMAN TUMOUR NECROSIS FACTOR	2013	Shingarova Ljudmila Nikolaevna Petrovskaja Lada Evgen'Evna Krjukova Elena Aleksandrovna Boldyreva Elena Filippovna Dolgikh Dmitrij Aleksandrovich Kirpichnikov Mikhail Petrovich	RU2531547C1

RU 2 530 553 C2

Authors

Tillib Sergej Vladimirovich

Efimov Grigorij Aleksandrovich

Nedospasov Sergej Arturovich

Kruglov Andrej Alekseevich

Drutskaja Marina Sergeevna

Dates

2014-10-10—Published

2012-11-07—Filed