FIELD: chemistry.
SUBSTANCE: invention relates to N-methoxybenzyl derivatives of daunorubicin of general formula I, where R=H, OCH3.
EFFECT: obtaining novel compounds having good antiproliferative properties with relatively low acute toxicity, which can be used in medicine for treating oncological diseases, in particular non-small-cell lung cancer, rhabdomyosarcoma, intestinal carcinoma, adenocarcinoma of the mammary gland.
1 cl, 1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-PYPERONYL DERIVATIVES OF DAUNORUBICINE, WITH ANTIPROFLIFERATIVE PROPERTIES | 2017 |
|
RU2642068C1 |
| PHOSPHONIUM SALTS ON BASIS OF PYRIDOXINE DERIVATIVES | 2011 |
|
RU2466728C1 |
| PYRIDOXIN AND ACETONE DERIVATIVES WITH ANTITUMOR ACTIVITY | 2017 |
|
RU2639879C1 |
| PYRIDOXINE DERIVATIVES WITH ANTICHOLINESTERASE ACTIVITY | 2014 |
|
RU2550080C1 |
| NON-STEROID ANTI-INFLAMMATORY AGENTS BASED ON PYRIDOXINE DERIVATIVES | 2012 |
|
RU2513089C1 |
| QUATERNARY AMMONIUM SALTS BASED ON DERIVATIVES OF VITAMIN B6 | 2015 |
|
RU2607522C1 |
| PHOSPHORUS-CONTAINING BETAINES WITH LIPOPHILIC OCTYL SUBSTITUENTS AT THE NITROGEN ATOM WITH BACTERICIDAL ACTIVITY | 2022 |
|
RU2794901C1 |
| ANTIBACTERIAL AGENTS ON BASIS OF CIPROFLOXACIN DERIVATIVES | 2016 |
|
RU2636751C1 |
| DIETHYL(3,5-BIS(ARYLIDENE)-4-OXOPIPERIDIN-1-YL)-(ARYL)-METHYLPHOSPHONATES HAVING ANTIPROLIFERATIVE PROPERTIES | 2015 |
|
RU2603194C1 |
| PHOSPHORYL SUBSTITUTED 3-KETO-ANDROST-4-ENE-[16,17-D]PYRIDAZINES AND METHOD OF THEIR PREPARATION | 2023 |
|
RU2807870C1 |
