FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, specifically to expression systems of therapeutic proteins, and can be used in therapy to form sensory cells in an individual's inner ear. Replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a protein homolog-1 protein of human atonal (Hath1), operably linked to a human glial fibrillary acidic protein (GFAP) gene promoter, is constructed.
EFFECT: invention enables effective stimulation of regeneration of sensory cells in the human inner ear.
15 cl, 2 dwg, 1 ex
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