ADENOVIRUS WITH DIRECTED GENE EXPRESSION AND USE THEREOF Russian patent published in 2010 - IPC C12N7/01 

FIELD: chemistry; biochemistry.

SUBSTANCE: invention relates to biotechnology. Recombinant adenovirus expresses a protein selected from a group comprising E1B and E4 proteins and their combination, and then a second protein which is E1A. Recombinant adenovirus consists of an expression cassette which codes E1B and E4 proteins under the control of a promoter which is different from the promoter which regulates expression in the wild type adenovirus. The recombinant adenovirus optionally contains nucleic acid which codes YB-1, expression cassettes which contain promoters and nucleic acids which code different genes. Disclosed also is a nucleic acid which codes such a recombinant adenovirus and use thereof.

EFFECT: recombinant adenovirus can be used in medicine for treating tumoural diseases.

30 cl, 26 dwg, 19 ex