FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. Described is a group of inventions comprising an aptamer binding GDF11, a method of detecting GDF11 in a sample, involving contacting proteins from a sample with said aptamer, and a composition for determining GDF11, comprising said aptamer and proteins from the sample. In one embodiment, the aptamer contains sequence 5'-RWnMCnCPPGMmMPPPAnACnMCmRWnPPGnPASnGC-3' (SEQ ID NO: 110) or 5'-RWnMCnCPPGMmMPPPAnACnMCmRWnPPGnPASnGS-3' (SEQ ID NO: 151) and binds GDF11 with affinity of less than 10 nM.
EFFECT: invention extends the range of products relating to GDF11.
53 cl, 3 dwg, 8 tbl, 6 ex
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