FIELD: medicine.
SUBSTANCE: invention relates to GDF/BMP antagonists for the treatment, prevention or reduction of the rate of progression and / or severity of pulmonary hypertension (PH), in particular the treatment, prevention or reduction of the rate of progression and/or severity of one or more PH-associated complications.
EFFECT: invention also provides methods for using GDF/BMP antagonists to treat, prevent, or reduce the rate of progression and/or severity of various conditions, including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, and right ventricular hypertrophy. The invention also provides methods of using a GDF / BMP antagonist to reduce right ventricular systolic pressure in a subject in need thereof.
22 cl, 23 dwg, 15 ex
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