OLIGONUCLEOTIDES CONTAINING MODIFIED NUCLEOSIDES Russian patent published in 2021 - IPC C12N15/115 A61K31/7115 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, in particular polynucleotides are presented, such as aptamers containing at least one first pyrimidine modified in the 5^th position and at least one second pyrimidine modified in the 5^th position, wherein the first and the second pyrimidines modified in the 5^th position are different. Methods for selection and use of such polynucleotides, such as aptamers, are also presented.

EFFECT: invention allows for obtaining aptamer with improved stability.

59 cl, 22 dwg, 17 tbl, 8 ex