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2 711 799

(13)

(51)

IPC

A61K31/70(2006-01-01)

A61K31/7105(2006-01-01)

A61K31/713(2006-01-01)

C07H21/02(2006-01-01)

C07H21/04(2006-01-01)

C12N15/113(2010-01-01)

(21) (22)

Application

2014101627, 2012-06-20

(24)

Start date

2012-06-20

(22)

Actual filing date

2012-06-20

(45)

Published

2020-01-22

(72)

Inventor

Bettenkort BrajanKuerbs UillyamFittszherald KevinFrank-Kamenetski MariyaMilstejn StyuartShulga-Morskaya Svetlana

(73)

Holder

Elnilem Farmasyutikalz, Ink.

MRNA COMPOSITION FOR PROTEIN SIMILAR TO ANGIOPOIETIN 3 (ANGPTL3) AND METHODS FOR USE THEREOF Russian patent published in 2020 - IPC A61K31/70 A61K31/7105 A61K31/713 C07H21/02 C07H21/04 C12N15/113

Abstract RU 2711799 C2

FIELD: chemistry.

SUBSTANCE: invention relates to biochemistry, particularly to double-stranded ribonucleic acid (dsRNA) for inhibiting ANGPTL3 expression, as well as to use thereof for inhibiting expression of ANGPTL3 in a cell and for treating an individual with a disorder, on which a favourable effect of reducing expression of ANGPTL3. Also disclosed is a pharmaceutical composition for inhibiting ANGPTL3 gene expression, containing an effective amount of said dsRNA.

EFFECT: invention provides effective inhibition of ANGPTL3 expression.

16 cl, 7 dwg, 16 tbl, 4 ex

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RU 2 711 799 C2

Authors

Bettenkort Brajan

Kuerbs Uillyam

Fittszherald Kevin

Frank-Kamenetski Mariya

Milstejn Styuart

Shulga-Morskaya Svetlana

Dates

2020-01-22—Published

2012-06-20—Filed