Show metadata Hide metadata

(19)

(11)

2 711 799

(13)

(51)

IPC

A61K31/70(2006-01-01)

A61K31/7105(2006-01-01)

A61K31/713(2006-01-01)

C07H21/02(2006-01-01)

C07H21/04(2006-01-01)

C12N15/113(2010-01-01)

(21) (22)

Application

2014101627, 2012-06-20

(24)

Start date

2012-06-20

(22)

Actual filing date

2012-06-20

(45)

Published

2020-01-22

(72)

Inventor

Bettenkort BrajanKuerbs UillyamFittszherald KevinFrank-Kamenetski MariyaMilstejn StyuartShulga-Morskaya Svetlana

(73)

Holder

Elnilem Farmasyutikalz, Ink.

MRNA COMPOSITION FOR PROTEIN SIMILAR TO ANGIOPOIETIN 3 (ANGPTL3) AND METHODS FOR USE THEREOF Russian patent published in 2020 - IPC A61K31/70 A61K31/7105 A61K31/713 C07H21/02 C07H21/04 C12N15/113

Abstract RU 2711799 C2

FIELD: chemistry.

SUBSTANCE: invention relates to biochemistry, particularly to double-stranded ribonucleic acid (dsRNA) for inhibiting ANGPTL3 expression, as well as to use thereof for inhibiting expression of ANGPTL3 in a cell and for treating an individual with a disorder, on which a favourable effect of reducing expression of ANGPTL3. Also disclosed is a pharmaceutical composition for inhibiting ANGPTL3 gene expression, containing an effective amount of said dsRNA.

EFFECT: invention provides effective inhibition of ANGPTL3 expression.

16 cl, 7 dwg, 16 tbl, 4 ex

Similar patents RU2711799C2

Title	Year	Author	Number
I-RNA COMPOSITIONS FOR SERPIN AND METHODS OF USE THEREOF	2013	Akink Akin Sekhgal Alfika Tudyarska Ivanka Foster Donald Milstejn Styuart Bettenkort Brajan Majer Martin Kharisse Klaus Kuchimanchi Satiyanarayana Radzhiv Kallantkhottatkhil G. Manokharan Mutkhiakh	RU2691580C2
METHODS AND COMPOSITIONS FOR TREATMENT OF BLEEDING PHENOMENON IN HEMOPHILIA PATIENTS	2018	Akinc, Akin	RU2801263C2
COMPOSITIONS AND METHODS FOR APOLIPOPROTEIN C-III (APOC3) GENE EXPRESSION INHIBITION	2012	Bettenkort Brajan Fittszherald Kevin Milstejn Styuart Majer Martin Kharisse Klaus Radzhiv Kallantkhottatkhil Kuchimanchi Satiya Manokharan Mutkhiakh Nguejn Tujen	RU2631805C2
RNAI AGENTS, COMPOSITIONS AND METHODS FOR USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES	2012	Radzhiv Kallantkhottatkhil G. Tsimmermann Trejsi Manokharan Mutkhiakh Majer Martin Kuchimanchi Satiyanarayana Kharisse Klaus	RU2678807C2
METHODS AND COMPOSITIONS FOR TREATMENT OF SERPINC1-ASSOCIATED DISORDER	2016	Akinc, Akin Sorensen, Benny Garg, Pushkal Robbie, Gabriel	RU2754188C2
MODULATING EXPRESSION OF ANGIOPOIETIN-LIKE PROTEIN 3	2014	Freier Susan M. Graham Mark J. Crooke Rosanne M.	RU2706964C2
TREATMENT OF DISEASES CONNECTED WITH SITE-1 MEMBRANE-IMPACTED PEPTIDASE OF TRANSCRIPTION FACTORS (MBTPS1), BY INHIBITING NATURAL ANTISENSE TRANSCRIPT TO MBTPS1	2010	Kollard Dzhozef Khorkova Sherman Olga	RU2639550C2
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)	2011	Bartts Stiv Braun Dunkan Robinson Majkl	RU2624045C2
TREATMENT OF SIRTUIN (SIRT) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SIRTUIN (SIRT)	2011	Kollard Dzhozef Khorkova Sherman Olga Kojto Karlos De Leon Belinda	RU2693462C2
TREATMENT OF FIBROBLAST GROWTH FACTOR 21 (FGF21) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO FGF21	2011	Kollard Dzhozef Khorkova Sherman Olga	RU2610661C2

RU 2 711 799 C2

Authors

Bettenkort Brajan

Kuerbs Uillyam

Fittszherald Kevin

Frank-Kamenetski Mariya

Milstejn Styuart

Shulga-Morskaya Svetlana

Dates

2020-01-22—Published

2012-06-20—Filed