FIELD: medicine.
SUBSTANCE: method of increasing site-1 gene expression membrane-impacted peptidase of transcription factors (MBTPS1), in cells or tissues of a mammal in vivo or in vitro, including: bringing these cells or tissues in contact with at least one antisense oligonucleotide comprising a length of 10 to 30 nucleotides, which specifically hybridizes with complementary plot of natural antisense polinucleotide, which has a sequence of SEQ ID NO: 2, and increases, due to this, the expression of the specified site-1 gene membrane-impacted peptidase of transcription factors (MBTPS1) in cells or tissues of a mammal in vivo or in vitro. Also presented an antisense oligonucleotide, at a length of approximately 10-30 nucleotides that contains at least one modification, where specified at least one modification is selected of: at least one of the modified fragment of sugar; at least one modified intenucleotid link; at least one modified nucleotide and their combinations; wherein the specified antisense oligonucleotide gibridizes with natural antisense polinucleotide of site-1 gene of membrane-impacted peptidase of transcription factors (MBTPS1) with a sequence of SEQ ID NO: 2, and increases, due to this, site-1 gene membrane-impacted peptidase of transcription factors (MBTPS1) in vivo or in vitro compared to control, and in doing so: the said oligonucleotide has sequence at least 80% identical to reverse complementary sequence to section of length of 10-30 nucleotides from the sequence SEQ ID NO: 2, or the specified oligonucleotide has sequence at least 80% identical to the section of 10-30 nucleotides in the sequence of SEQ ID NO: 1. Moreover, the composition is described, containing submitted an antisense oligonucleotide and method of preventing or treating disease associated with site-1 gene membrane-impacted peptidase of transcription factors (MBTPS1) and/or PIN specified gene MBTPS1 product, including use of submitted antisense oligonucleotide.
EFFECT: FIELD: increased efficiency.
24 cl, 1 dwg, 2 ex
