METHOD FOR CORRECTION OF CEREBRAL ISCHEMIA WITH RAPITALAM SUBSTANCE IN EXPERIMENTS Russian patent published in 2020 - IPC G09B23/28 A61K31/165 A61P9/10 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology and neurology, and can be used for treating cerebral ischemia. Method involves reproducing a four-vessel model of cerebral ischemia by coagulation of two vertebral arteries and temporary occlusion of two common carotid arteries. Wistar male rats are intraperitoneally injected with the substance of Rapitalam 10 mg/kg 30 minutes prior to modeling the pathology on the first day of the experiment and after simulating cerebral ischemia daily for 14 days.

EFFECT: method provides marked cerebral ischemia correction by targeted action of Rapitalam on mGluR4 receptors, resulting in inhibition of production of glutamate in a black substance, protection from glutamate-mediated excitotoxicity and suppression of inflammatory effects.

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