METHOD FOR PREVENTION OF ISCHEMIA OF RETINA WITH ERYTHROPOETIN EXPERIMENTALLY Russian patent published in 2015 - IPC G09B23/28 A61K38/18 A61P27/02 

Abstract RU 2539629 C1

FIELD: medicine.

SUBSTANCE: method involves simulating retinal pathology and preventing it by administering recombinant erythropoietin as a preconditioning agent into a laboratory animal. Erythropoietin is administered daily once on the first experimental day intragastrically in a dose of 50 IU/kg 30 minutes before simulating the pathology. The method promotes the pronounced correction of ischemia of the retina ensured by a mechanism of opening of ATP-dependent K+-canals followed by inducing mechanisms of metabolic adaptation in implementing the preconditioning effect.

EFFECT: preventing the ischemic conditions of the retina.

1 ex, 1 tbl

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RU 2 539 629 C1

Authors

Arustamova Anna Aleksandrovna

Pokrovskij Mikhail Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Shabel'Nikova Anna Sergeevna

Kashuba Anastasija Sergeevna

Jakushev Vladimir Ivanovich

Korokina Lilija Viktorovna

Alekhin Sergej Aleksandrovich

Kolesnik Inga Mikhajlovna

Dates

2015-01-20Published

2013-07-05Filed