FIELD: medicine.
SUBSTANCE: method involves simulating retinal pathology and preventing it by administering recombinant erythropoietin as a preconditioning agent into a laboratory animal. Erythropoietin is administered daily once on the first experimental day intragastrically in a dose of 50 IU/kg 30 minutes before simulating the pathology. The method promotes the pronounced correction of ischemia of the retina ensured by a mechanism of opening of ATP-dependent K+-canals followed by inducing mechanisms of metabolic adaptation in implementing the preconditioning effect.
EFFECT: preventing the ischemic conditions of the retina.
1 ex, 1 tbl
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Authors
Dates
2015-01-20—Published
2013-07-05—Filed