METHOD FOR PREVENTION OF BRAIN ISCHEMIA Russian patent published in 2018 - IPC G09B23/28 A61K31/498 A61P25/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental pharmacology and neurology, and can be used to prevent ischemic brain conditions. Method includes a preliminary, prior to modeling the ischemic state of the brain, administration of a preconditioning agent to the laboratory animal. As such an agent, tadalafil is used at a dose of 1 mg/kg, which is injected once intragastrically through the probe. After 60 minutes, a simulation of cerebral ischemia is performed by coagulation of two vertebral arteries and temporary occlusion of two common carotid arteries.

EFFECT: method provides a frank correction of cerebral ischemia in an animal during the experiment due to the induction of tadalafil mechanisms of metabolic adaptation and the realization of preconditioning effect.

1 cl, 4 dwg, 1 ex, 6 tbl