PYRROLIDINE DERIVATIVES AS PPAR AGONISTS Russian patent published in 2020 - IPC C07D207/08 C07D403/12 C07D409/06 A61K31/4025 A61K31/4155 A61P1/16 A61P3/04 A61P3/06 A61P5/50 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a compound of formula (I)

and a pharmaceutically acceptable salt thereof. In the compound of formula (I): R₁ is selected from H, NH₂ or C_1-6 alkyl, C_3-6 cycloalkyl, 3-6-membered heterocycloalkyl, phenyl, 5-6-member heteroaryl, each of which is optionally substituted with 1, 2 or 3 R; R₂, R₃ are independently selected from H, halogen or C_1-3 alkyl, optionally substituted with 1, 2 or 3 R; X is selected from O or S; if X is selected from O or S, then R₄ is selected from H or C_1-3 alkyl, optionally substituted with 1, 2 or 3 R; R₅ is selected from H, halogen or CH₃, CH₃-S(=O)-, CH₃-S(=O)₂-, CH₃S, each of which is optionally substituted with 1, 2 or 3 R; n is selected from 0, 1, 2 or 3; ring A is selected from phenyl or 5-6-member heteroaryl; L₁ is selected from a single bond, -C(=O)-, -O-, -NH-, -C(=O)O-, -C(=O)NH-, -S(=O)₂-, -S(=O)-, -(CRR)_1-3-; L₂ is selected from a simple bond, -(CRR)_1-3-, -O-, -S-; L₃ is selected from -(CRR)-, -C(=O)-; L₄ is selected from a simple bond, -(CRR)_1-3-; R is selected from H, F, Cl, Br, I or C_1-3 alkyl, each of which is optionally substituted with 1, 2 or 3 R'; R' is selected from F, Cl, Br, I; "Hetero-" refers to a heteroatom or heteroatomic group and is selected from -NH-, -O-, -S-; in any of the cases defined above, the number of heteroatoms or heteroatomic groups is independently selected from 1, 2 or 3. Also disclosed are specific compounds, a pharmaceutical composition and use of the compound of formula (I).

EFFECT: obtaining novel compounds, pyrrolidine derivatives, as PPAR agonists and use thereof for treating diseases associated with pathways associated with the PPAR receptor.

28 cl, 1 tbl, 84 ex