FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing γ-amides of glutamic acid of formula , where R4 is an amino-protective group selected from a carbobenzyloxy group (CBz), R5 is a straight or branched C1-C10alkyl, R2 and R3 independently represent a hydrogen atom, R-NH2 is a 3-amino-derivative of bile acid, which are further capable of reacting to form valuable organic compounds - ligands, complexes with ions of paramagnetic di-tri-valent metals selected from a group consisting of Fe(2+) Fe(3+), Cu(2+), Cr(3+), Gd(3+), Eu(3+), Dy(3+), Yb(3+) or Mn(2+) of which can serve as a base for preparing diagnostic compositions for use in NMR-tomography of the blood circulatory system of humans and animals.
EFFECT: design of an efficient method of producing γ-amides of glutamic acid.
1 cl, 20 ex
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Authors
Dates
2010-07-27—Published
1999-12-16—Filed