FIELD: biochemistry.
SUBSTANCE: present invention relates to a compound of the formula or its pharmacologically acceptable salt, wherein: B is selected from a group consisting of:
R1 and R3 independently represent CH or N; R2 represents CH or С=O; R5-R9 independently represent С or N; Q is independently selected from an alkyl, hydroxy, amino, and substituted amine selected from a group consisting of -NHSO2CH3, -NHCOH, -NHCONHCH3, -NHCONHCH2CH3, -NHSO2NHCH3, -NHSO2NHCH2CH3 and -NHCOCH3; n is equal to 0, 1 or 2; D represents:
R10-R14 independently represent С, N or S; Т is independently selected from С1-6alkyl and halogen; and m is equal to 0, 1, 2, 3 or 4, in this case, D cannot be an unsubstituted phenyl, and Q cannot be a hydroxy when n is 1 and all R5-R9 represent С. In addition, the invention relates to the compound
and its pharmacologically acceptable salt, to a method for the preventive or therapeutic treatment of pulmonary fibrosis or a related condition in a subject with pulmonary fibrosis or at risk of developing pulmonary fibrosis, including the introduction of the above compounds, as well as to the use of these compounds for the manufacture of a drug for the preventive or therapeutic treatment of pulmonary fibrosis.
EFFECT: new compounds that can be useful in treatment of pulmonary fibrosis have been obtained and described.
16 cl, 5 dwg, 3 ex
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Authors
Dates
2021-05-14—Published
2017-07-28—Filed