COMPOSITIONS FOR PULMONARY FIBROSIS TREATMENT Russian patent published in 2021 - IPC C07C235/34 C07D213/56 C07D333/24 C07D207/327 C07D307/54 C07D231/12 C07D239/26 C07D277/30 C07D261/08 C07C235/78 C07C237/20 C07H15/203 A61K31/165 A61K31/381 A61K31/402 A61K31/4418 A61K31/415 A61K31/426 A61K31/192 A61K31/7034 A61P11/06 A61P11/00 

FIELD: biochemistry.

SUBSTANCE: present invention relates to a compound of the formula or its pharmacologically acceptable salt, wherein: B is selected from a group consisting of: R₁ and R₃ independently represent CH or N; R₂ represents CH or С=O; R₅-R₉ independently represent С or N; Q is independently selected from an alkyl, hydroxy, amino, and substituted amine selected from a group consisting of -NHSO₂CH₃, -NHCOH, -NHCONHCH₃, -NHCONHCH₂CH₃, -NHSO₂NHCH₃, -NHSO₂NHCH₂CH₃ and -NHCOCH₃; n is equal to 0, 1 or 2; D represents: R₁₀-R₁₄ independently represent С, N or S; Т is independently selected from С_1-6alkyl and halogen; and m is equal to 0, 1, 2, 3 or 4, in this case, D cannot be an unsubstituted phenyl, and Q cannot be a hydroxy when n is 1 and all R₅-R₉ represent С. In addition, the invention relates to the compound and its pharmacologically acceptable salt, to a method for the preventive or therapeutic treatment of pulmonary fibrosis or a related condition in a subject with pulmonary fibrosis or at risk of developing pulmonary fibrosis, including the introduction of the above compounds, as well as to the use of these compounds for the manufacture of a drug for the preventive or therapeutic treatment of pulmonary fibrosis.

EFFECT: new compounds that can be useful in treatment of pulmonary fibrosis have been obtained and described.

16 cl, 5 dwg, 3 ex