FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of phenyl or pyridine substituted with Qn, or condensed ring structures as follows; Q is independently selected from halogen, alkyl, hydroxy, amino and substituted amino; n is 0, 1, 2, 3, 4 or 5; R1, R3 and R4 are independently C, CH, CH2, O, N, NH or S, and R2 is C, CH, CH2, N, NH, C-CF3, CH-CF3 or C=O; wherein, if n is 1, Q can not be hydroxy; substituted amino has the formula –NHW, where W is selected from -CN, -SO2(X)aY and -CO(X)aY, a is 0 or 1, X is selected from -NH- and -O-, and Y is selected from -H, -CH3, -CH2CH3, -CH2OH and -CH2CH2OH, and where the links between R1 and R2, R2 and R3, R3 and R4 independently represent double or single bonds. Invention also relates to a pharmaceutical composition having anti-arthritic effects and/or antifibrotic effects comprising an effective amount of the compound or a pharmaceutically acceptable salt thereof of formula (1) and a pharmaceutically acceptable adjuvant.
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EFFECT: compounds of the invention are intended for the treatment of hypertension, prehypertension and fibrosis.
18 cl, 22 ex, 21 dwg
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