FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely to ophthalmology, and can be used for treatment or prevention of disease, disorders or conditions caused by endoplasmic reticulum stress in endothelium of cornea. That is ensured by using a therapeutic or preventive agent in the form of eye drops containing a NGF-beta signalling pathway inhibitor. Preferably, the signalling pathway inhibitor contains 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide, as well as an additional pharmaceutical ingredient selected from kinase inhibitors Rho or steroids.
EFFECT: group of inventions provides a method of producing a therapeutic prophylactic agent for diseases, disorders or conditions caused by endoplasmic reticulum stress in the corneal endothelium.
15 cl, 14 dwg, 15 ex
| Title |
Year |
Author |
Number |
| THERAPEUTIC AGENTS DIRECTED TO THE ECM OF THE CORNEAL ENDOTHELIA |
2019 |
- Koizumi, Noriko
- Okumura, Naoki
- Kinoshita, Shigeru
|
RU2800931C2 |
| DRUG CONTAINING mTOR INHIBITOR FOR TREATMENT OR PREVENTION OF EYE SYMPTOMS, DISORDERS, OR DISEASES, AND ITS USE |
2018 |
- Koizumi Noriko
- Okumura Naoki
|
RU2782613C2 |
| COMPOSITION OR A METHOD COMPRISING (T)EW-7197 FOR THE TREATMENT OR PREVENTION OF CORNEAL ENDOTHELIAL DISEASES |
2018 |
- Koizumi Noriko
- Okumura Naoki
- Yamamoto Mayumi
|
RU2798396C2 |
| MEDICATION, METHOD OF OBTAINING MEDICATION, AND METHOD OF TREATMENT FOR CORNEA EDEMA AND OTHER EARLY BULLOUS KERATOPATHY MANIFESTATIONS |
2008 |
- Kasparov Arkadij Aleksandrovich
- Kasparova Evgenija Arkad'Evna
- Pavljuk Aleksandr Sergeevich
|
RU2357743C1 |
| HETEROCYCLIC COMPOUND AS INHIBITOR OF CASEIN KINASE 1δ AND/OR ACTIVIN RECEPTOR-LIKE KINASE 5 |
2021 |
|
RU2810065C1 |
| NEW CORNEAL TREATMENT WITH LAMININ |
2015 |
- Koizumi Noriko
- Okumura Naoki
- Kinosita Sigeru
|
RU2718062C2 |
| BENZYLIDENEGUANIDINE DERIVATIVES AND THERAPEUTIC USE THEREOF FOR TREATMENT OF PROTEIN MISFOLDING RELATED DISEASES |
2014 |
- Geda Filipp
- Berotolotti Enn
|
RU2654910C2 |
| LIVER ORGANOID, VERSIONS OF USE THEREOF AND CULTURE METHOD FOR PRODUCTION THEREOF |
2011 |
- Uch Ortega Meritksel
- Klevers Jokhannes Karolus
|
RU2579995C2 |
| ANGIOPOIETIC ANGIOPOIETIN-LIKE PROTEIN 4 INHIBITORS, IN COMBINATIONS AND APPLICATION |
2005 |
- Ferrara Napoleone
- Gerber Khans-Peter
- Ljan Sjao Khuan
|
RU2392966C2 |
| USING LAMININ IN CORNEAL ENDOTHELIAL CELL CULTURE |
2014 |
- Koizumi Noriko
- Okumura Naoki
- Kinosita Sigeru
- Kruze Fridrikh E.
- Shlettser-Shrekhardt Ursula
|
RU2704984C1 |
