THERAPEUTIC AGENTS DIRECTED TO THE ECM OF THE CORNEAL ENDOTHELIA Russian patent published in 2023 - IPC A61K31/00 A61K31/4439 A61K45/00 A61K39/395 A61P27/02 

Abstract RU 2800931 C2

FIELD: medicine; ophthalmology.

SUBSTANCE: invention is intended for the treatment of a disease, disorder or condition caused by Fuchs endothelial corneal dystrophy. A medicinal product containing an agent that inhibits the TGF-beta signal is used to treat a disease, disorder or condition caused by an abnormality of the extracellular matrix (ECM) in the corneal endothelium in a subject, where the disease, disorder or condition is due to Fuchs endothelial corneal dystrophy. The drug is eye drops.

EFFECT: use of the invention provides effective treatment of a disease, disorder or condition caused by Fuchs endothelial corneal dystrophy by inhibiting ECM overexpression.

6 cl, 9 dwg, 6 ex

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RU 2 800 931 C2

Authors

Koizumi, Noriko

Okumura, Naoki

Kinoshita, Shigeru

Dates

2023-08-01Published

2019-03-15Filed