ACTIVATED ANTIBODIES WHICH BIND TO EPIDERMAL GROWTH FACTOR RECEPTOR, AND METHODS FOR USE THEREOF Russian patent published in 2020 - IPC C07K16/28 C07K16/46 C12N15/13 C12N15/63 A61K39/395 A61P35/00 G01N33/53 C12P21/08 

FIELD: biotechnology.

SUBSTANCE: invention relates to the biotechnology. Disclosed is an activated antibody which, when activated, binds an epidermal growth factor receptor (EGFR), comprising an antibody, a masking fragment, which in unsplated condition inhibits binding of antibody with EGFR, and splitted fragment, which functions as substrate for protease. Also disclosed are: a nucleic acid encoding an activated antibody; vector; methods for producing an activated antibody; a method of treating or delaying the progression of EGFR related disorder; a method for inhibiting angiogenesis; method for detecting presence or absence of a cleavable agent and EGFR; method and kit for identifying or specifying a population of patients for treating EGFR related disorders; use of an activated antibody in the manufacture of a medicinal agent.

EFFECT: activated antibody of the present invention has reduced toxicity and can find further application in therapy.

70 cl, 23 dwg, 9 tbl, 12 ex