FIELD: medicine; pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmaceutics, namely to an isolated polypeptide cleaved by matrix metalloproteinase 14 (MMP14), which is found in tissue together with a target, containing the following arrangement of structures from N-end to C-end: MM-CM-AB or AB-CM-MM, where MM is a masking fragment, SM is a cleavable fragment and AB is an antibody or antigen-binding fragment of an antibody which binds to a target; where SM is a substrate for protease, which is located in tissue together with target; and where CM contains an amino acid sequence selected from the group consisting of SEQ ID NO: 364-370 and 14, where the cleavable fragment is a substrate for MMP14, where cleavage by MMP14 activates said recovered peptide.
EFFECT: cleavage by MMP14 of the recovered polypeptide in the cleavable fragment.
16 cl, 7 dwg, 10 tbl, 14 ex
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