PROTON-BINDING POLYMERS FOR ORAL ADMINISTRATION Russian patent published in 2020 - IPC C08F271/00 A61K31/785 C08F226/02 C08F8/02 C08F26/04 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing a cross-linked amino-containing polymer, as well as to a cross-linked amino-containing polymer. Said method involves cross-linking a preformed amine polymer in a reaction mixture to form a cross-linked amine polymer. Reaction mixture contains a pre-formed amine polymer, a solvent, a crosslinking agent and a swelling agent for the preformed amine polymer. Pre-formed amine polymer has an absorption capacity of the swelling agent. Amount of the swelling agent in the reaction mixture is lower than the capacity of absorption of the swelling agent which the previously obtained amine-containing polymer has. Weight ratio of the swelling agent to the pre-formed amine-containing polymer in the reaction mixture is 1:1. Solvent is introduced at the crosslinking step to disperse the pre-formed cross-linked polymer grains.

EFFECT: obtained polymer has the ability to remove protons and chloride ions from the gastrointestinal tract in an animal, including a human.

25 cl, 6 dwg, 32 tbl, 10 ex