METHOD FOR SIMULTANEOUS DETERMINATION OF DEGREES OF OXIDATION AND ALKYLATION OF AZOXIMER BROMIDE - ACTIVE SUBSTANCE OF POLYOXIDONIUM - BY METHOD C NMR SPECTROSCOPY Russian patent published in 2020 - IPC G01N24/08 

FIELD: technological processes; pharmaceutics.

SUBSTANCE: use for simultaneous determination of degrees of oxidation and alkylation of azoximer bromide. Summary of invention consists in the fact that, using method ¹³C NMR spectroscopy, spectrum signals are related ¹³C polyoxydonium with specific methylene groups of N-oxide 1,4-ethylene piperazine and (N-carboxymethyl)-1,4-ethylene-piperazinium, identifying their characteristic signals and measuring values of normalized integral intensities of characteristic signals of the same number of methylene groups of N-oxide 1,4-ethylene piperazine and (N-carboxymethyl)-1,4-ethylene-piperazinium.

EFFECT: possibility of identifying a pharmaceutical substance "Polyoxidonium" and dosage forms based on it, confirming the presence of the main structural fragments and determining their molar ratio – oxidation and alkylation degree.

3 cl, 6 dwg