FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to a combined pharmaceutical composition for preventing or treating cardiovascular diseases. Composition contains a first mixture containing amlodipine, chlorothalidone and a pharmaceutically acceptable additive which is lactose hydrate and microcrystalline cellulose at a weight ratio of 1:0.5 to 1:2, and a second mixture containing losartan and an additive. First and second mixtures are contained in physically separated forms. Combination composition according to the invention is preferably a two-layer tablet. Also described is a method of producing a combined composition and a two-layer tablet.
EFFECT: combined composition of the invention is characterized by high degrees of solubility of amlodipine, losartan and chlorthalidone and improved stability during storage.
8 cl, 13 dwg, 12 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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|
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| COFORMULATED DRUG FOR CARDIOVASCULAR DISEASES BASED ON CHRONOTHERAPY THERAPY | 2007 |
|
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| METHOD OF TREATING CARDIOVASCULAR DISEASES | 2012 |
|
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| PHARMACEUTICAL COMPOSITION CONTAINING AMLODIPINE AND LOSARTAN | 2007 |
|
RU2401107C2 |
| PHARMACEUTICAL COMBINED DRUG | 2014 |
|
RU2639818C2 |
| TABLET AND METHOD OF ITS PREPARATION | 2019 |
|
RU2796301C2 |
