FIELD: medicine.
SUBSTANCE: described is a pharmaceutical combination formulation for the cardiovascular diseases treatment. Composition includes first individual portion comprising amlodipine, rosuvastatin, lactose hydrate and microcrystalline cellulose as additives, and second individual portion comprising losartan. Lactose hydrate is contained in amount of 20 to 40% and microcrystalline cellulose is contained in amount of 50-70% of the first individual portion total weight. These individual portions are physically separated from each other. Also described is the pharmaceutical combination formulation in the form of tablet preparation process, according to which the second individual portion components mixture with losartan is granulated by roller compacting to obtain granules.
EFFECT: combination formulation according to the invention comprising amlodipine, losartan and rosuvastatin exhibits satisfactory storage stability and of amlodipine, losartan and rosuvastatin dissolution rate.
7 cl, 16 dwg, 10 tbl, 6 ex
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